Note:This is a bare minimum checklist and guide for Resident Evil 2. The steps outlined below is from a speedrun, so take what you need along the way or go back to areas when you need to.
Leon A Checklist /
Prologue
Enter the Gas station. Get Storage Door Key and exit the gas station.
R.P.D
Open East Door, enter Watchman's Room and pickup the Notebook. Exit and go back to Main Hall.
Open taped box, enter Reception and pickup Handgun Ammo. Proceed along the West hallway to the Operations Room then exit via top window.
Proceed to 3F stairs, and pickup Spade Key then down the West Office. Open Safe and pickup Hip Pouch and exit using the Spade Door to the Main Hall.
Proceed up the East stairs to Waiting Room. Enter Art Room and pickup the Weapons Locker Keycard then exit the room.
Sprint towards the Fire Escape and pickup the Bolt Cutters and enter precinct door.
Enter the East Office and pickup both Flash Bang, Valve Handle, and Fuse. Exit via the blocked door and use the Fuse on the electrical box on your way back to the Main Hall.
Walk thru Reception and West hallway towards the Operations Room. Open the door to the back room. Pickup Detonator and Flash Grenade then exit via east door.
Enter Safety Deposit Room. Use the Weapon Locker Keycard and pickup the Shotgun and Shotgun Shells.
Sprint towards the 2F Shower Room. Use the Valve and proceed to the S.T.A.R.S. Office. Pickup the Battery, Shotgun Shells, and Flash Grenade.
Proceed to the 3F West Storage Room. Use the Detonator (and Battery) on the Gate (Exit the door to the Library and back into the room to prevent the shelf blocking the door). Solve the Maiden Statue and get the Medallion.
Enter side door to the Library and down the stairs to the Lounge. Solve the Unicorn Statue and get the second Medallion. Go back thru the Library and enter the Main Hall.
Solve the Lion Statue and pickup the Medallion and use the three Medallions on the Main Hall Statue's base.
Enter the Secret Room. Pickup the Shotgun Shells and enter the elevator. Continue walking thru the corridors till you reach the Machinery Room for a... BOSS FIGHT!
Loot the area of items then up the ladder. Hit the lever and cross the catwalk to the Operators room and pickup the Hip Pouch. Use the ladder up.
Parking Garage
Use the Card Reader on the gate. Follow Ada to the reporter. Pickup the Square Crank and go back to the Parking Garage.
Enter the East door and down to the Kennel and thru the back door. Use the Square Crank to open the shutters.
Go thru the East door to the Generator Room. Pickup the Electonic Part and operate the Power Panel on the North West corner of the room.
Make your way back thru the Kennel to the just unlocked door then up the stairs.
Get the Shotgun Shells from the open shelf. Enter the Break Room and pickup Blue Herb and the Fuse near the beds. Proceed to the east corridor and open the shutter by using the Fuse.
Enter Watchman's Room and up the Fire Escape and to the precinct's 2F. Use the Square Crank to open the North shutter. Proceed up the stairs to the 4F.
Enter the East Storage Room and pickup the Large Gear, doubleback and exit the room. Pickup the Flash Grenade from one of the lockers and exit thru the door to the East.
Down the ladder and stairs from the Balcony. Use the water pump lever and enter the Boiler Room and get the Club Key. Go back to the stairs and use the release lever to extinguish the burning helo.
Enter the West door. Pickup the Red Herb. Meet Mr. X and run past him. Pickup the Green Herb and make your way back to the Main Hall via the East Office.
Make your way to the Reception and thru the West hallway and unlock the Records Room with the Club Key. Pickup the Grenade and Jack Handle. Then make your way back to the Main Hall.
Up the stairs to the Library. Use the Jack and move the left-most bookcase (twice). Up the ladder and cross the bookcases to the Main Halls 4F's corridor.
Clock Tower
Enter the Clock Tower. Use the Large Gear. Pick up the Large Gear and up the stairs. Remove the Small Gear and replace it with the Large Gear. Go back down. Use the Small Gear and pickup the Electrical Part and exit the room.
Go thru the Library Door and drop down via the broken floorboards. Proceed with a long trek back to the the Jail. (Main Hall, East Office, Watchman's Room, East hallway, then along the Firing Range, Parking Garage)
Use both Electrical Parts and solve the puzzle. Enter the cell and pickup First Aid Spray and the Parking Permit. Exit the Jail and use the Card Reader.
Follow Ada thru the Gun Shop. Pickup Grenade, Shotgun Upgrade, and Handgun Ammo. Exit the back door and thru the scaffoldings to the Sewers.
Pick up the Handgun Ammo and get chased by the BAG (Big Ass Gator!). Pickup the Grenade then up the ladder with Ada to the elevator.
Ada
Use the gadget on electical box and the fan and climb the ladder. Then use the gadget again on the fan and electical box. Hack the north-most electical box and up the small elevator.
See Mrs. Birkin, enter the room and hack the east electrical box and the electrical box up top when the door opens. Pop the fan and exit.
Go up the stairs and use the incinerator lever. Enter the incinerator and pickup the Wristband. Hack the electrical boxes to escape and head to now unlocked door to the East.
Sewers
Dropdown to the Sewers and take the right tunnel and up the stairs. Run past the Rook Plug to the left hallway and down the stairs on the right. Proceed up the stairs and ladder to the Monitor Room and exit thru the door on the left.
Use the switch and cross the Treatment Pool Room. Turn West and pickup the T-Wrench and down some flight of stairs to the sluce gate blocking the Lower Waterway. Flip the switch and pickup the Grenade at the back and go thru the Lower Waterway and up the first bank on the right.
Open the locked door using the T-Wrench and enter the Workroom Lift. Pickup the Shotgun Shells and use the lift. Deal with the zombie and pickup the Hip Pouch. Exit the door and pickup the Rook Plug and double back down the lift.
Drop down the sewers and go back to the up the sluce gate and take the left path. Use the T-Wrench on the door, cross the catwalk and down the ladder. Take the left bank and continue North with the G-Adults and enter the door to the Supplies Storage Room.
Navigate the doors in the Supplies Storage Room and leave the room with the Queen Plug, King Plug and the Flamethrower.
Drop again in the mucky water and deal with the G-Adults as you see fit. Take the left path and up the ladder to the catwalks. Proceed back to the Monitor Room and solve the Chess Plugs to unlock the door.
Pick up the Green Herb and make way to the Main Power Room. Solve the Power Panel and... It's Mr Birkin. Exit thru the door on the left and down to a shipping container and a control panel. BOSS FIGHT! Unlock the door and exit with Ada.
Cross the Treatment Pool Room with Ada to the Cable Car.
NEST Lab
At the Reception, enter the East door and head towards the Cafeteria and pickup the Grenade. Up the ladder and down to the Kitchen. Pickup the Combat Knife.
Enter the Nap Room, pick up the Shotgun Shells, Flamethrower Regulator, and Wristband Upgrade Chip. Head back towards Reception.
Enter the Security Room, pickup Shotgun Shells and head towards the East Area, unlocking paths using the upgraded wristband.
Go thru the East Area Lobby to the Presentation Room then finally to the Greenhouse Control Room. Enter the two Greenhouse Codes and then take the Dispersal Cartridge.
Exit via the left door to the Greenhouse and proceed to the Drug Testing Lab. Use the Dispersal Cartridge and solve. Pickup the Grenade before you leave.
Down the ladder to the sub-basement and to the Lounge. Deal with the zombies/Lickers here and head north and up a flight of stairs and pickup the Signal Modulator. Doubleback to the Lounge and use the Signal Modulator on the circuit breaker with the vending machines.
Proceed to the Low-Temp Testing Lab. Head inside the cold room and use the Dispersal Cartridge. Then head stright back the to the Greenhouse Control Room and insert the Herbicide. Head outside and pickup the Wristband Upgrade Chip and start heading towards the West Area.
Enter the West Area and pickup the Grenade along the way. Use the Signal Modulator on the circuit breaker. Proceed to the room and pickup the G-Virus. Doubleback and BOSS FIGHT! Pick-up the items around the arena then head up back to the main elevator.
Escape the lab! Pickup the Combat Knife and Green Herb along the way. Meet Mr. X and evade. Upon reaching the platform, stock up and pickup the Joint Plug.
Use the Joint Plug on the platform console. BOSS FIGHT! Deal with Mr. X. Exit the platform thru the door.